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In addition, setmelanotide is pioneering a personalized medicine approach to obesity, specifically targeting very rare genetic disorders such as pro-opiomelanocortin (POMC) deficiency, proprotein convertase subtilisin/kexin type 1 (PCSK1) deficiency, and leptin receptor deficiency

10.1158/2159-8290.CD-13-0286 11 BartolacciC.AndreaniC.ValeG.BertoS.MelegariM.CrouchA

Another study [44] with uremic patients with some degree of muscular atrophy, reports that 24-week treatment with l-carnitine (2 g IV at the end of hemodialysis, or in dialysis solution, or per os twice daily) leads to an increase of about 7% in the diameter of type I and type IIa fibers, as well as to a reduction in atrophic fibers

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