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Health concerns rarely arrive in neat little boxes

Thus, in bioprocesses such as the transformation of trimethylammonium compounds, in which substrate and product transport and activation are associated to energy and the performance of the bioprocess involves the mobilization of cellular cofactors, strain improvement by metabolic engineering is also a strategy of prime importance, since new cell catalysts can be purposely devised [26, 72]

54 The observation that deficiency of Puma (or combined deficiency of Puma and Noxa or Puma and p21) promoted the development of C-myc-driven lymphoma, 107,108 which suggested that p53-mediated apoptosis could exert obvious tumor-suppressive effects

Lancet 352 , 455456 (1998)