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These processes involve tumor-intrinsic pathways and microenvironmental interactions, offering three interventional strategies for DTP tumors: pharmacological disruption of stress adaptation pathways, therapeutic intensification to induce catastrophic stress overload or exploitation of metabolic vulnerabilities (Fig

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PubMed Duzel, A., Vlainic, J., Antunovic, M., Malekinusic, D., Vrdoljak, B., Samara, M., Gojkovic, S., Krezic, I., Vidovic, T., Bilic, Z., Sjekavica, I., Djuzel, A.R., Knezevic, M., Sever, A.Z., Lojo, N., Kokot, A., Sever, M., Drmic, D., Seiwerth, S., Sikiric, P