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EPZ6438 shifts macrophages from an M2 to an M1 phenotype by reducing H3K27me3 on STAT3 promoters, whereas GSK126 has the opposite effect, revealing distinct immunomodulatory roles for the two EZH2 inhibitors (44)
J Porphyr Phthalocyanines 15:555559
All animals were shown to be susceptible to tumour growth with comparable growth curves between the mouse strains that promotes the application of the new mouse for efficacy studies
