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University of Texas Medical Branch researchers show that treating with an inhibitor of an enzyme that breaks down an NAD+ precursor enhances muscle strength and endurance and shortens recovery time in aged mice.

Here the authors report a phase I clinical trial assessing the safety of clinically formulated TS in mesothelioma patients, and identify SLC7A11 as a potential mediator of TS resistance in pre-clinical models.

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While the heart-specific targets of MOTS-c are still being investigated, these findings open the door to the peptides potential use in supporting cardiovascular health