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doi: 10.1016/j.cmi.2023.12.019

These drugs, by reducing muscle overactivity, can also attenuate spasticity-mediated NP

ALC counteracts oxidative stress and senescence by up-regulating Heat-shock proteins, Nrf2 signalling, HO-1, and SOD and promotes the transcription of the Grm2 gene [158, 166, 167, 170, 185]

Su aparicin produce retrasos en la administracin de un nuevo ciclo, reducciones de la dosis por ciclo o incluso suspensiones del tratamiento