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Two transmembrane domains (TMDs) provide the transport mechanism and are powered by the nucleotide-binding domains (NBDs) that hydrolyze ATP

Inhibition of MMP-9 degradation, stabilization of endothelial cytoskeletal proteins, and Rho kinase pathway-mediated cytoskeletal remodeling have been shown to alleviate lung injury (Mller et al., 2019

2-Bromoisobutyryl bromide (BIBB) is commonly employed as the initiator because it reacts with the catechol and amine groups in PDA through nucleophilic acyl substitution, forming ester and amide bonds, respectively

Of note, Trx2 is localized to the mitochondria and has been found to play an important role in limiting mitochondrial ROS production and regulating cardiac function 10,11