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To date, only six substances have made it through the process to be put on the list, none of which are peptides and none of which are injectables

In an animal model of fetal alcohol disorders, T4 expression was upregulated in protective microglial cells of the stress-sensitive hippocampus, and giving exogenous T4 reduced activation of pro-inflammatory networks and their secretion of cytokines including TNF, IL-1, and iNOS

The same HGF plasmid (VM-202) was also evaluated in ALS patients in order to define its tolerability and safety profile (NCT02039401)

Figure 2: Results of the MTT assay following 48 hour incubation with the peptide Furthermore, PNC-27 led to leakage of LDH after the 24 hour treatment period with the peptide, in a dose-dependent manner