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Wang et al., 2020a)

Dietary nucleotides and gut mucosal defence

Their proposed therapeutic action is paracrine that is, they release a cocktail of bioactive molecules that: Provide neurotrophic support (BDNF, GDNF, and other factors that help surviving neurons stay alive) Reduce chronic neuroinflammation through anti-inflammatory cytokines and modulation of microglial activation Promote vascular health and support cerebral perfusion through angiogenic signals (e.g., VEGF) Provide immunomodulation that may attenuate the chronic immune dysregulation observed in PD This is a fundamentally different therapeutic concept from cell-replacement: rather than adding new dopamine producers, MSC therapy aims to slow loss of those that remain