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This Knowledge Summary by Fiona Douglas explores this clinical question and what the evidence shows
Cool DR, Normant E, Shen F, Chen HC, Pannell L, Zhang Y, Loh YP (1997) Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice

R., Jacques, P

The most common adverse effect that DiStefano observed are dosing errors
