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Description
The key anti-oxidative transcription factor, nuclear factor E2 related factor 2 (Nrf2 or NFE2L2), plays a dominant role in defense machinery by reprogramming the iron, intermediate, and glutathione peroxidase 4 (GPX4)-related network and the antioxidant system to attenuate ferroptosis

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During this phase, two key regulatorsHIF-1 (the critical mediator of hypoxia response) and BMAL1 (the central component of the circadian rhythm)orchestrate the activities of bone-regenerating cells, ensuring proper cellular function and orderly progression of bone repair
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