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Recruitment for ME/CFS patients started just before COVID related restrictions were introduced and research was suspended: one patient and one healthy control were recruited in February 2020, others from February 2021

doi: 10.1039/c9ob00744j 49 SuhailS.ZajacJ.FossumC.LowaterH.McCrackenC.SeversonN.et al

IL-1beta is increasingly understood as a major regulator of tumor promoting inflammation through its activity on different components of tumor microenvironment including recruitment of tumor infiltrating myeloid cells, angiogenesis, and suppression of anti-tumor immune response [112,113]

Enzymatic reactions, such as those involving cytochrome P450, xanthine oxidase, and nitric oxide synthase, can also produce free radicals [14]
