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doi: 10.1016/j.ccr.2011.01.038 42 YaeTTsuchihashiKIshimotoTMotoharaTYoshikawaMYoshidaGJet al
Electron microscopy studies have shown that the S protein itself is a trimer consisting of three S1 heads and a trimeric S2 stalk, which is an essential structural property for the binding and invagination of the target host cell [28, 29]
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Interestingly, this tamoxifen-induced differentiation occurs in a PKC signaling independent-manner, and not only by activation of classical estrogen receptors but also by activation of GPER-1 (Gonzalez et al., 2016)
