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Step 3: GHK-Cu and PDRN topical application through open microchannels Immediately following the microneedling session, GHK-Cu serum is applied to the treatment area while the microchannels are fully open

The most common degradation pathways include: Oxidation of methionine, cysteine, and tryptophan Hydrolysis and deamidation , which occur faster in the presence of moisture Microbial contamination , which affects reconstituted solutions Aggregation , especially in hydrophobic sequences Light and oxygen exposure , which accelerate oxidation Stability directly affects binding activity, mass accuracy, solubility, and overall experimental reliability

Likewise, remarkable safety (i.e., LD50 higher than 2000 mg/kg through oral or intravenous route in mice) confirmed no adverse effect in toxicology studies (none of the animals died)

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