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Bowers 1991 first characterized its GH-releasing activity

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BPC-157 also influences the expression of additional growth factors including epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), and the early growth response gene EGR-1

Considerable heterogeneity exists among the reported results, commonly attributed to differences in underlying patient comorbidities, a lack of consistent surgical stress, changes in anesthetic pharmacology, and different outcome measures techniques, making strategies to minimize the risk of PAN difficult to develop (2530)