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Analysis of retinas from a glaucoma mouse model fed the KD demonstrated reduced AMPK activation, which was associated with lower NF-B p65 nuclear translocation and decreased expression of pro-inflammatory molecules (40)
doi: 10.1159/000314310
Indeed, compound Z30702029 inhibited GSDME-N-terminal domain-mediated pyroptosis in preclinical experiments (127)
Hyperhomocysteinemia: Clinical Insights
