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Santen, R

Tumors often suppress MHC I through gene deletion, transcriptional inhibition, or degradation pathways

A 260-pound man approaches 205

From a clinical perspective, this mechanistic evidence reinforces existing guidance to use paracetamol at the lowest effective dose for the shortest possible duration, to avoid repeated highdose selfmedication, and to carefully document indication, timing, and cumulative exposure during pregnancy (Dathe and Schaefer, 2019[26])
