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10.1371/journal.pgen.1002526 PLoS Genet
This is most commonly thought of in terms of oral bioavailability, where an orally administered drugs bioavailability depends on the extent of gastrointestinal absorption and hepatic first-pass elimination: where F is the absolute bioavailability, AUC po is the AUC with oral dosing, AUC iv is the AUC with intravenous dosing, D po is the oral dose administered, and D iv is the intravenous dose administered
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