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It widens the blood vessels in the brain and improves the blood supply to the nerve cells
Sestrins inhibit mTORC1 kinase activation through the GATOR complex

Upon interaction with 2-fluorinated ASOs, paraspeckle proteins can be degraded, a mechanism that substantially contributes to ASO toxicity 13

Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts
