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After injury, the kidney reprograms to shift its energy reliance, which increases its oxygen consumption, becoming more vulnerable to hypoxia and oxidative injury 16,17

Inhibition of Rho GEFs attenuates pulmonary fibrosis through suppressing myofibroblast activation and reprogramming profibrotic macrophages

These symptoms are not only associated with many chronic diseases, but are also a result of mitochondrial dysfunction, which occurs when mitochondria lose the protection of GSH, free radicals attack the mitochondria, and cellular energy decreases

[DOI] [PMC free article] [PubMed] [Google Scholar] Raphel V., Giardina T., Guevel L., Perrier J., Dupuis L., Guo X.J., Puigserver A
