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Moreover, the consistency of these findings across multiple clinical trials, different patient populations, and varying doses further solidifies tesofensine's promising efficacy profile

Presente de forma natural en nuestro cuerpo, donde se sintetiza a partir de los aminocidos lisina y metionina, la L-Carnitina es un compuesto orgnico con la importante funcin de unirse a los cidos grasos de cadena larga y conducirlos hasta el interior de la mitocondria para llevar a cabo su metabolismo

doi: 10.7199/ped.oncall.2019.30 147 SunnyJMAbrencilloR

The reduction of metabolic flexibility, mitochondrial dysfunction, and accumulation of ectopic lipids, particularly in the liver and adipose tissue, promote a state of inflammaging, which is further aggravated by the diminished amplitude and robustness of endogenous rhythms in both the SCN and peripheral metabolic organs (Cardinali and Hardeland, 2017