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The discovery of molecular chaperones originated from studies on cellular stress responses

A crucial piece of evidence comes from the study of the deprotonated molecules of heavy metal-biothiol conjugates ( i.e

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Although this latter study using Dm GPx was based on high-definition crystallographic data for GPx-4, molecular modeling suggests that the Asn may also be essential in GPx-1 (359) and that the functional catalytic site is actually a tetrad