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In contrast, conjugation of rucaparib to IR-786 reduced the IC 50 from 53 M to 0.02 M
The most informative translational signals for ferroptosis are indicators of the defining biochemical dependencies: accumulation of phospholipid hydroperoxides in membrane lipids, catalytic iron permissiveness, and suppression or remodeling of ferroptosis suppressor systems
The clinical signal is less clear
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