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See additional relevant data comparing synaptic structure in humans and rats in Molnr et al

All control groups received the appropriate vehicle solutions
These measures are invaluable for screening, monitoring, and proof-of-concept, but a change in an imaging fat fraction or a blood panel is a surrogate: it supports, but does not by itself establish, the biopsy endpoints regulators require

Cells 10(10):2533 Baig S et al (2016) Potential of apoptotic pathway-targeted cancer therapeutic research: where do we stand