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When glucose is present in the blood at excessively high levels, it reacts spontaneously with proteins, lipids, or nucleic acids to form advanced glycation end products (AGEs)

The basis of the pathological change is the cells inability to prevent protein misfolding, to revert misfolded proteins to normal, or to eliminate misfolded proteins by degradation

The choice depends on (1) the per-research-unit amount specified in the research protocol, (2) preference for syringe increment precision, (3) the peptide's solubility characteristics, and (4) how quickly the reconstituted vial will be used (lower volumes concentrate more research doses in a smaller volume of reconstituted solution)

It is commonly supplemented as L-aspartic acid, the bioavailable form for feed inclusion