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Indications: Huntington's Chorea (a hyperkinetic movement disorder) A drug of first choice for this condition Side Effects: Sedation Depression (suicidal tendencies) Parkinsonism symptoms Lacks the hypotensive & GI side effects of reserpine due to its selectivity for central VMAT2 Pharmacokinetics: * undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 active metabolites -dihydrotetrabenazine (-HTBZ) and -dihydrotetrabenazine (-HTBZ), with eventual renal elimination of metabolites the -HTBZ and -HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent prodrug Readily crosses the blood brain barrier & depletes cerebral monoamine stores

Your body produces it naturally, primarily in the liver, where it functions as one of the most important antioxidants in human biology

[DOI] [PMC free article] [PubMed] [Google Scholar] Bonilla F.A, Oettgen H.C

10.1038/s41580-019-0159-6 73 GuanH.-R.LiB.ZhangZ.-H.WuH.-S.WangN.ChenX.-F.et al (2024)