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The prototypic genetic deficiency is loss-of-function mutations in the gene encoding the protein proFLG (Hoober and Eggink, 2022
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If these peptides are so safe and effective, why aren't they licensed medicines

Maintain aseptic handling to preserve compound integrity
Studies have documented analgesic effects comparable to moderate doses of conventional pain medications in animal models, with prolonged duration of action extending beyond the peptide's short plasma half-life suggesting central nervous system mechanisms of action
