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This mechanism is thought to account for the rewarding effects of 9 -THC and other cannabinoid drugs, and is also likely to be a prominent mechanism through which eCBs contribute to brain mechanisms of reward

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However, in the non-senescent control fibroblast model cultured in 10% FBS DMEM treated with or without FOXO4-DRI (25 M), no SA--gal-positive cells were observed both in keloid fibroblasts and in normal skin fibroblasts (Supplementary Fig