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Genetic variations in immune-response and inflammatory pathways can predispose some individuals to heightened sensitivity to peptide compounds

In a study performed to dissect the role of mGlu2 and mGlu3 receptors in the endogenous control of inflammatory pain, mice lacking mGlu2 receptors showed amplification of pain in the second phase of the formalin test, which reflects the development of nociceptive sensitization in the spinal cord [165]
