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Daratumumab earned approval for monotherapy due to its efficacy, safety profile and durable responses demonstrated in the phase 1/2 GEN501 and the phase 2 SIRIUS clinical trials on heavily pretreated RRMM patients [71, 72]

The medicinal form depends on how well it is absorbed in the body and factors such as age, genetics, and the condition of the digestive system

The CAS acknowledged these observations in its findings, noting that they carried no weight as evidence but describing them as "at least not inconsistent" with the timeline of the program

Anti-Inflammatory Signaling: Researching the reduction of C-reactive protein (CRP) and other markers of chronic metabolic inflammation