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64,65 In particular, because CKD contributes to the progression of cardiovascular disease through many pathways, the authors of a 2021 review published in Circulation stated that CKD mimics an accelerated aging of the cardiovascular system. 66 Blood Clot and Bleeding Risks Chronic kidney disease increases the risk of bleeding events as well as blood clots (thrombosis) and related health problems

Medical Hypotheses, 68 (6), 12961299

Similarly, co-administration of absorption enhancers (e.g., piperine from Piper nigrum) can inhibit P-glycoprotein efflux and cytochrome P450 metabolism, improving the bioavailability of lipophilic TCM ingredients [191]

PMID: 32799362