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The summary of alterations in ferroptosis-related genes and proteins across various models used in this study can be viewed in Supplementary Table 3

Senescence is characterized by a stable cell cycle arrest and multiple phenotypic changes, including the secretion of a wide array of pro-inflammatory cytokines, proteases, and other factors collectively known as the senescence-associated secretory phenotype (SASP) ( As several of the changes associated with senescence can also be observed in other cellular states, proper identification of cellular senescence requires the presence of multiple hallmarks

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The advantage to sequence native DNA (without PCR amplification biases or harsh bisulfite treatment) and long and ultra long reads coupled with epigenetic states of the DNA allows to accurately estimate DNA methylation levels in transposable elements