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The metabolite morphine-6-glucuronide contributes to the analgesia produced by morphine infusion in patients with pain and normal renal function

For title/abstract screening, full-text review, and data extraction, two independent researchers reviewed articles, and a third researcher resolved conflicts

Lin SH, Raju GS, Huff C, Gu J, Chen JS, Kopetz S , Menter DG, Hawk E, Mishra L, y Y, Wu X

In this study, the scientists assessed cell apoptosis through caspase-3 activation and found out that the apoptosis of the treated group was significantly lower than that of the untreated group, indicating that fibrin matrix supplemented with perfluorodecalin loading can provide a beneficial physical and chemical environment for improved islet in vitro