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Early diagnosis and treating underlying causes help achieve long-term recovery and prevent complications

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a hypothalamic C-terminally amidated 38 residue peptide hormone originally characterized on the basis of its ability to stimulate cAMP accumulation from anterior pituitary cells (431)

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Due to this symmetry mismatch, the bottom of ATD and top of the LBD domains of only the distal subunits are in close apposition and interact with each other unlike the ATD and LBD domains of the proximal subunits