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Description
Well-formed granulomas result from this cell-mediated response to antigenic stimuli [23]
Underlying is an mTORC1/c-Myc pathway of stromal glucose and amino acid metabolism, which causes increased stromal IL-6 production that is required for tumor promotion
Employing melatonin as an immunomodulatory agent therefore may require higher dosages to be effective, for example in murine models, a dose of 10mg/kg is widely used to investigate the anti-inflammatory and tissue-protective actions of melatonin (18, 2931, 70)
PMID: 163 LealJ
