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GPX4 is the only cellular enzyme that specifically reduces phospholipid hydroperoxides to lipid alcohols using GSH as a co-factor 4 , and inhibiting the cyst(e)ine/GSH/GPX4 axis induces the strongest cell death in most cellular contexts

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Glutathione is naturally produced in the liver and plays a key role in neutralizing free radicals, repairing tissues, and maintaining healthy skin

11 The deposition of iron in the SN region from autopsy studies is also supported by independent MRI-based studies using quantitative susceptibility measurements (QSM)