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it is also a major NAD + consumer with a lower K m than most NAD + -consuming enzymes 40 and is implicated in the decline of NAD + levels observed during aging and disease 5052

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In addition to triggering ADCC, CD38 ligation can induce direct activation of NK cell cytotoxicity and, although it may lead to depletion of CD38 high NK cells, it retains the population of cytotoxic NK cells [32, 33]

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4 5 This is the study that most cleanly demonstrates the desired dissociation: fat mobilization on one hand, preserved glucose handling on the other

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