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Description
4D), we did not observe an increase in p21 expression upon treatment with MQ, the active metabolite of APR-246 (Supplementary Fig
It has been demonstrated that enhanced glutamine metabolism results in the accumulation of toxic ammonia levels, which in turn damages lysosomes and mitochondria, leading to T-cell depletion
Studies have shown that metformin is correlated with TCA cycle, lipid metabolism, glucose metabolism, although the results were inconsistent between studies and not enough to derive robust conclusions
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