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In very rare cases, they could have a severe allergic reaction called anaphylaxis

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For example, phosphorylation of signal transducer and activator of transcription 3 (STAT3) at Ser727 has been shown to be an important node through which toll-like receptor 4 (TLR4) mediates metabolic reprogramming and promotes IL-1 production, thereby providing a new mechanistic entry point for integrating receptor signaling-metabolic flux-inflammatory output (136)

These findings suggest that reduced degradation of the N-terminal leads to an improvement in metabolic stability [2]