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Previous studies showed that reduced fatty acid oxidation and increased lipid accumulation promote nuclear translocation of DVE-1 and ATFS-1, 45 which not only activate genes related to mitoUPR but also upregulate the metabolic regulator nhr-80 , 46 which in turn activates the diacylglycerol acyltransferase dgat-2 to promote TAG synthesis 46 and upregulates fatty acid desaturases fat-5 and fat-7 to promote PUFA production
Our recommendations also do not encompass considerations of the additionally complex and unique needs of individuals with ASD and a co-occurring genetic disorder such as Rett Syndrome or Fragile X syndrome

[PubMed] [Google Scholar] Rossi AC, Mullin PM
