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The antioxidant enzymes of AsA-GSH pathway help in maintaining ROS homeostasis in cells by avoiding the potential cytotoxicity of ROS and allowing them to function as signal molecules

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In mouse embryonic fibroblasts, the elevation of CHAC1 protein expression following As III exposure is negatively regulated by the Tribbles homolog 3 (TRIB3), which limits CHAC1s pro-death potential ( 6 A methylation