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Many immunomodulatory drugs also inhibit TGFB, reduce plasma levels of IL1 and IL1B, and prevent activation of NFkB

161 A comprehensive review that included 28 studies with a combined total of 2,733 participants experiencing tinnitus for at least three months found CBT may reduce the negative effect of tinnitus on quality of life

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A consistent reduction of the annualized relapse rate was noted in subgroups defined by sex, age group, prior multiple sclerosis therapy, and baseline disease activity