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In this study, mice homozygous for Nnt WT or Nnt Tr (N5-WT or N5-Tr mice) were obtained by crossing heterozygous N5BL/6J Nnt WT/Tr mice
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As TNR has previously been shown to interact with voltage-gated Na + channels (Na v s) 46 , this effect may be due to the TNR perturbation affecting Na v activity, which may, in turn, increase the excitability of the neurons
