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Exposure to high levels of Cu has been linked with pancreatic neuroendocrine tumours and prostate cancer ( Recently it has been shown that enhanced levels of Cu upregulate the expression of programmed death ligand 1 (PD-L1) in tumour cells and modulate the signalling pathways that mediates the PDL-driven immune escape by cancer cells ( Cu has the ability to switch on many pro-angiogenic responses and aid the proliferation and mobility of endothelial cells, which initiates angiogenesis that provides oxygen and essential nutrients to tumours ( Copper Chelators and Ionophores in Cancer Cu homeostasis in cancers is emerging as an attractive target for anti-cancer drug development
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Consent forms alone are not sufficient
MiyamotoJOhue-KitanoRMukouyamaHNishidaAWatanabeKIgarashiMet al
