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In the phase III LEONARDA-1 trial, lerociclib combined with fulvestrant significantly improved progression-free survival (PFS) in patients with endocrine therapy-resistant breast cancer while maintaining a favourable safety profile [27]

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Cell Death Dis 14(7):434

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doi: 10.1146/annurev.immunol.20.083001.084359 348 HeilM

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Netrin-1 upregulates GPX4 and prevents ferroptosis after traumatic brain injury via the UNC5B/Nrf2 signaling pathway

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