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In the next sections, we will briefly introduce thiazides, thiazide-like and loop diuretics from a historic perspective to illustrate how the success of one specific class of these diuretics in treating hypertension overshadowed their undesired metabolic effects and reduced our curiosity to study them to better understand their basic and clinical pharmacology

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Zhao S, Mi Y, Guan B, Zheng B, Wei P, Gu Y, Zhang Z, Cai S, Xu Y, Li X, He X, Zhong X, Li G, Chen Z, Li D

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Although hyperphosphorylated tau is a central hallmark of AD pathology, p-tau analysis is not included in the present manuscript because it is part of a separate, dedicated study currently under independent peer review

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LL-37: Antimicrobial Defense and Mucosal Immunity Mechanism of Action: LL-37 is a cathelicidin antimicrobial peptide that supports innate immunity and protects the gut lining from microbial invasion

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