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2.4 Ions and miRNAs 2.4.1 Calcium Ca 2+ is the most widespread intracellular messenger ( 2+ release through the TRPML1 channel, which activates TFEB by calcineurin and promotes autophagy (Medina et al., 2015)

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we summarized a few of them that have relatively clearer therapeutic indications based on RCT results

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