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References: Ishida J et al

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Both treatments can cause digestive upset, so you should: Start berberine at a low dose and increase gradually if tolerated, to minimise gastrointestinal side effects Maintain adequate hydration , particularly if experiencing diarrhoea Report persistent or severe symptoms to your healthcare provider, as these may indicate poor tolerance of the combination Regarding contraception, semaglutide does not reduce oral contraceptive bioavailability

To determine the K m and k cat values of mIDH2 catalyzing isocitrate decarboxylation, the concentrations of isocitrate were 1.00, 0.460, 0.230, 0.116, 0.058 and 0.029 mM, while the NADP + concentration was maintained at the saturating level of 1.00 mM