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These issues might be overcome by targeting more specifically CD38 by employing pre-targeting systems

Yu H, Zhou X, Wang Y, Huang X, Yang J, Zeng J, Li G, Xie X, Zhang J (2020) Nicotinamide N -methyltransferase inhibits autophagy induced by oxidative stress through suppressing the AMPK pathway in breast cancer cells
Both compounds have demonstrated favorable safety profiles in preclinical and early clinical research, but combination use has not undergone Phase III human trials

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