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These findings suggest that AS-IV exerts synergistic neuroprotective effects at the multicellular level by simultaneously targeting the JNK apoptotic pathway and the NLRP3 inflammatory pathway ( Another study demonstrated that atractylenolide-I (ATR-I), the primary active component of Atractylodes macrocephala Koidz., exhibits significant neuroprotective effects in PD models

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This is owing to the some organic acid accumulation (Rinaldo et al., 1998, Thangavelu, 2010)

[DOI] [PubMed] [Google Scholar] 28.Stasiowicz-Krzemie A., Nogalska W., Maszewska Z., Maleszka M., Dobro M., Szary A., Kpa A., arowski M., Hojan K., Lukowicz M., et al